Pathophysiology Of Paroxysmal Nocturnal Dyspnoea

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Paroxysmal nocturnal hemoglobinuria is a rare disease in which red blood cells break down earlier than normal.

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Causes, incidence, and risk factors

Persons with this disease have blood cells that are missing a gene called PIG-A. This gene allows a substance called glycosyl-phosphatidylinositol (GPI) to help certain proteins stick to cells.

Without PIG-A, important proteins cannot connect to the cell surface and protect the cell from substances in the blood called...

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