Other Causes of Persistent Fatigue. A number of conditions can cause persistent fatigue and should be ruled out:
- Obstructive sleep apnea. This is a major sleep disorder that causes fatigue and afternoon sleepiness and must be ruled out before a diagnosis of narcolepsy can be established. (A person may also suffer sleep apnea and narcolepsy at the same time.)
- Chronic fatigue syndrome
- Head trauma
- Infectious mononucleosis

- Guillain-Barre syndrome
- Hepatitis
- Atypical pneumonia, particularly those involving echoviruses
Other Causes of Sleep Paralysis. Sleep paralysis may be triggered by certain conditions, such as:
- Irregular sleep habits
- Sleep deprivation
- Shift work
- Jet lag
- Psychologic stress
These conditions may also worsen sleep paralysis in narcolepsy. Narcolepsy sleep paralysis usually occurs at the onset of sleep and is chronic.






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