Full Question: I have been suffering migraines for over 35 years ,and although find relief with Imitrex, oral and injectable, I have just learned that taking antidepressants such as Effexor (350mg daily) may not be in my best interest. Lately my headaches are lasting longer in duration and shorter time lapses in between. I also suffer from diarrhea along with my migraines, something I don’t often hear about. Of course I am vomiting during the attacks as well. What could I take instead of Imitrex (Effexor factor)? Also is it normal to have such violent diarrhea along with migraines, I feel almost as I have been poisoned and my body is trying to rid itself of everything. Thank you in advance for taking time to answer. Linda.
The potential problem with antidepressants and triptans is serotonin syndrome, which is very rare. Please take a look at another recent answer HERE. Diarrhea is often a symptom of Migraine as is vomiting. Some patients do well with over-the-counter medications such as Imodium for diarrhea. Mention this to your doctor so he can suggest something appropriate for you.
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