Experts in dementia and Alzheimer’s disease have long been looking for ways to reverse memory deficits and cognitive impairments in order to treat and prevent these brain conditions. A new mouse study from Temple University breaks through previously established barriers by identifying cellular pathways critical to developing dementia and offering potential treatments even after the disease is established.
The study, published online in the journal Molecular Neurobiology, shows that tau pathology, an important lesion in the brains of people with Alzheimer’s disease, could possibly be reversed with medical intervention. Researchers pursued the study after discovering the important role of inflammatory molecules known as leukotrienes in dementia and Alzheimer’s.
Mice were engineered to develop tau pathology. Some were then treated with a drug that inhibits leukotriene formation. The treated mice experienced a 90-percent reduction in leukotriene levels compared to the untreated mice. The lead author says that the study shows that intervention may be possible even after dementia is established and offers new hope for patients living with Alzheimer’s and dementia.
Sourced from: Temple University Health Systems