Alka Seltzer is born: Feb. 21, 1931

A pharmaceutical legend is born when Miles Laboratories, a company based in Elkhart, Indiana, unveils a new product that promises "quick relief" from everything associated with the flu--pain, headaches, upset stomach and fever. It's called Alka-Seltzer and it's an effervescent tablet that does its work after bubbling away to nothing in a glass of water.

A few years earlier, during a severe flu outbreak, the president of Miles, a man named Hub Beardsley, had heard from a local newspaper editor that he had kept his staff from getting sick by giving them a combination of aspirin and baking soda. Beardsley quickly asked his chief chemist to come up with a similar concoction. The result is a tablet that combines aspirin, sodium bicarbonate and citric acid.

It didn’t hurt that two years later Prohibition ended in the U.S., just as Alka-Seltzer was catching on as a cure for hangovers. But what really made the fizzy medication a household name is the company's ambitious use of mass media to promote its brand. By 1932, it was already sponsoring a radio show, "The Alka-Seltzer Comedy Star of Hollywood," followed by a series of popular music programs for the next 20 years.

Then, as Americans began buying their first TV sets in the early 1950s, the company caught that wave, too. In 1954, it introduced a cute little mascot--a red-haired boy named Speedy, with an Alka-Seltzer body and an Alka-Seltzer hat. Using a six-inch high puppet and stop-motion animation, the TV ads brought Speedy to life, making him dance and sing, "Plop, plop, fizz, fizz...Oh, what a relief it is."  Over the next 10 years, he appeared in more than 200 different commercial. The character became so famous that the puppet was insured for $100,000.

By the mid-1960s, when Speedy began feeling old-fashioned to a younger audience, the brand shifted gears again and started producing a series of funny ads that became some of the more iconic commercials of the 1960s and 1970s, and featured lines that were widely mimicked, from "Mamma mia, that's-a spicy meat ball!" to "I can't believe I ate the who-o-o-o-o-le thing!"

After 1979, Miles Laboratories was no more, bought out by Bayer. But, today, 84 years later, Alka-Seltzer lives on.

More slices of history

First penicillin shot: Feb. 12, 1941

Longest surgery: Feb. 4-8, 1951

First Social Security check: Jan. 31, 1940

**Prohibition starts: Jan. 16, 1920