Angiolymphatic Invasion


Asked by sanorita

Angiolymphatic Invasion

what does angiolymphatic invasion mean? my mom has been diagnosed with stage 2 IDC, she had mastectomy and her path report: with margins clear but with angiolymphatic invasion, no nodes involved, ER/PR is (2/8) neg and HER2 is (2%) weakly positive...

How can angiolymphatic invasion happen when no node are involved. or can we say that angiolymphatic invasion was within her breast and as she has been done with mastectomy, So she is safe. she does not want to take up chemo....?


Angiolymphatic invasion means that cancer was found in the blood vessels and lymph vessels. Since your mother didn't have any positive lymph nodes, it sounds like the cancer may not have spread beyond the breast. There is no way to know for certain. The lymph vessels in the breast are connected to the body's entire lymphatic system. We also have lymph nodes in other areas near the breast like under the breast bone and near the collar bone. Most of the lymph vessels in the breast drain to the lymph nodes under the arm, and the nodes under the arm are the easiest to sample.

There is never a guarantee that cancer has not left the breast even when the margins appear clear and the nodes are negative. The surgeons have some good clues that they "got it all." When they are not sure, they like to recommend a systemic treatment like chemo which reaches every part of the body. They hope to kill any escaping cells that way.

Your mother's doctors can give her their best guess about whether she needs chemo. Then she can decide what she wants to do. If your mother is resisting chemo because she has heard horror stories about the chemo side effects, she needs to know that new medications do a much better job of managing side effects. Some women breeze right through; most people have a few, but not all, of the possible side effects. If she starts chemo and decides it is too hard, she can discontinue it.

Answered by Phyllis Johnson