Has Anyone Tried Nortriptyline For Migraine Treatment?


Asked by michelle

Has Anyone Tried Nortriptyline For Migraine Treatment?

My doctor just prescribed Nortriptyline HCL for chronic migraine prevention. Has any taken this for migraines? What are the side effects? Thanks.


Hi Michelle,

Nortriptyline, aka Pamelor, is a tricyclic antidepressant and is sometimes used to treat migraine disease. A few things to keep in mind when starting a new drug - it may take up to three months to adjust to it and see a reduction in migraine frequency.

The potential side effects of nortriptyline include:

  • breathing problems
  • liver problems
  • recent heart attack
  • problems urinating (such as due to enlarged prostate)
  • overactive thyroid (hyperthyroidism)
  • a certain eye problem (glaucoma)
  • personal or family history of mental/mood conditions (such as bipolar disorder, psychosis)
  • family history of suicide
  • seizures
  • conditions that may increase your risk of seizures (such as other brain disease, alcohol withdrawal)

Side effects are potential which means patients may or may not experience them. If you find this medication is not reducing your migraine frequency, don't lose hope. There are over 100 medicationa available for Migraine prevention.

Good luck,

Nancy Bonk

Answered by Nancy Harris Bonk