Can broccoli fight cancer?
Compounds found in broccoli, Brussels sprouts and other cruciferous vegetables may help prevent the recurrence and spread of some cancers, according to a new study at South Dakota State University.
When cancer is treated with chemotherapy or radiation, the tumor disappears, but the cancer stem cells live on. So the researchers tested a compound called PEITC that’s produced when these vegetables are chewed, to see what effect they have on cancer stem cells. In one case, the scientists treated human cervical cancer stem cells in a petri dish with PEITC, and they found that almost 75 percent of the cells died within 24 hours when a high concentration of the compound was used. In another, they found that lower concentrations of the compound significantly prevented the spread of cancer in the lung tissue of mice.
The researchers noted that the concentrations of the compound they used in the lab can be achieved through diets rich in certain types of cruciferous vegetables, such as broccoli and watercress.
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Sourced from: Science Daily, Plant-derived compound targets cancer stem cells
Published On: May 6, 2015
"Watson" supercomputer to guide personalized cancer treatments
The trend toward developing highly personalized cancer treatments based on a patient’s DNA is taking a big leap foward. More than a dozen U.S. and Canadian cancer institutes will start using the IBM supercomputer known as “Watson” to precisely identify drugs that can be most effective at treating a tumor based on its genetic footprint.
While experts agree that chemotherapy and radiation will remain the standard of care for many common cancers, matching a person’s treatment to their DNA is increasingly being seen as a key to the future of fighting cancer.
It can take weeks or longer to identify which drugs can be most effective against a particular tumor, Watson can provide an answer in minutes from its enormous database of scientific papers and clinical trials on particular cancers and potential therapies. do it in minutes and has in its database the findings of scientific papers and clinical trials on particular cancers and potential therapies.
By the end of 2015, Watson will be helping doctors at a total of 14 cancer institutes, including the Cleveland Clinic, the Fred & Pamela Buffett Cancer Center in Omaha and Yale Cancer Center. The centers will pay a subscription fee for the service, which IBM has not disclosed. Oncologists will upload the DNA fingerprint of a patient’s tumor, which indicates which genes are mutated and possibly driving the malignancy. Then Watson, famous for beating two champions of the game show Jeopardy! in 2011, will sift through thousands of mutations and try to identify which is driving the tumor, and what drug would be most effective.
Steve Harvey, vice president of IBM Watson Health, has said that Watson could match patients with approved or experimental cancer drugs, but also possibly non-cancer drugs.
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Sourced from: Reuters, IBM’s Watson to guide cancer therapies at 14 centers
Published On: May 6, 2015