Cancer cells hide from immune system
Researchers at Ohio State University say one of the keys to improving cancer treatments may revolve around a molecule that helps cancer cells hide from the body's immune system.
Their study has found that manipulating a molecule called NF-kB, which helps cancer cells avoid attacks from the immune system, could lead to the development of more effective immunotherapy in cancer patients. They said their research suggests that immunotherapy could be more effective if it combines drugs that inhibit NF-kB.
They noted that NF-kB interacted with cells during tumor formation in mice and found that the molecule helped cancer cells survive initial immune responses to the tumor. The researchers also determined that the molecule was helped suppress an immune response.
This research shows promising developments for immune therapy, particularly in treating cancers such as melanoma.