A small study published in Proceedings of the National Academy of Sciences, suggests that ibuprofen – the nonsteroidal anti-inflammatory drug (NSAID) found in many over-the-counter pain relievers and fever reducers, like Advil, Motrin, and others – may reduce fertility levels in young men.
The study involved 31 men between 18 and 35. Fourteen of them were given the maximum recommended daily dose of ibuprofen (600 milligrams, twice per day) and 17 were given a placebo. Within 14 days, men taking the ibuprofen experienced testicle dysfunction indicated by a decreasing ratio of testosterone to luteinizing hormones, which are secreted by the pituitary gland and stimulate the testicles to produce testosterone.
A small percentage of these young men developed a hormonal imbalance resulting in a condition called compensated hypogonadism, according to the researchers. This condition, which is associated with impaired fertility, depression, and an increased risk for heart failure and stroke, usually doesn’t begin until middle age.