Could Weakened Bones Signal Dementia Risk?


Several studies have suggested that osteoporosis — thinning bones — is associated with an increased risk for cognitive changes and memory loss. Researchers at the Epidemiology Team of IQVIA, a multinational health information technologies and clinical research company in Frankfurt, Germany, conducted a retrospective study to look at possible links between osteoporosis and cognitive decline.

This study used data from IQVIA’s Disease Analyzer database, which includes information about prescriptions, diagnoses, and demographics, obtained directly and anonymously from computer systems in 1,200 German health care providers’ offices. The same information had already been used in several previous studies examining links between osteoporosis and dementia.

The researchers analyzed data from nearly 60,000 study participants (29,983 with osteoporosis and 29,983 controls without osteoporosis) who had been monitored for up to 20 years. At the end of the follow-up period, 20.5 percent of women and 22 percent of men with osteoporosis had been diagnosed with dementia, while 16.4 percent of women and 14.9 percent of men without osteoporosis were diagnosed with dementia. Osteoporosis was associated with a 1.2 times higher risk for dementia in women and a 1.3 times higher risk in men.

Sourced from: Journal of Alzheimer’s Disease