Current Migraine and Headache Clinical Trials

Patient Expert

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Clinical trials of medications and other treatments for Migraines, headaches, and other conditions are conducted for a variety of reasons. They gather data to determine if medications and other treatments are effective, if they're safe, what potential side effects they may have. Clinical trials also study particular symptoms, the effects of Migraine and other conditions on the body and various organs, and many other things.

Participating in clinical trials can be one way to help add to the body of medical knowledge and evidence and to try medications and treatments not yet available.

Below, is a list of clinical trials which are enrolling participants for various trials related to Migraine and other headache disorders. For more information about any of these trials, simply click the link. This listing will be updated monthly.

A Multicenter Study to Evaluate the Efficacy of DR-105 for Menstrually-Related Migraine Headaches ClinicalTrials.gov Identifier: NCT00781456 Condition: Migraine Interventions: Drug: DR-105; Other: Placebo

Medicine Abuse Headache ClinicalTrials.gov Identifier: NCT01170793 Condition: Migraine Intervention: Behavioral: educative telephone coaching (ETC)

Determine Central 5-HT1B Receptor Occupancy of ZOMIG® Rapimelt (Zolmitriptan) in Healthy Male Volunteers ClinicalTrials.gov Identifier: NCT01085123 Condition: Migraine Interventions: Drug: Rapimelt; Drug: [11C]AZ10419369

A Study of Family-based Cognitive-behavioral Therapy for Chronic Pediatric Headache and Anxiety ClinicalTrials.gov Identifier: NCT01182051 Conditions: Pediatric; Headache; Anxiety Intervention: Behavioral: CBT or relaxation training

Does Treximet Improve Productivity and Patient Satisfaction Due to Sustained Response and Consistency of Response? ClinicalTrials.gov Identifier: NCT01086358 Condition: Workplace Migraine Treatment Interventions: Drug: Usual prescribed triptan; Drug: Treximet for Migraine treatment

Determine Central 5-HT1B Receptor Occupancy of ZOMIG® Rapimelt (Zolmitriptan) in Healthy Male Volunteers ClinicalTrials.gov Identifier: NCT01085123 Condition: Migraine Interventions: Drug: Rapimelt; Drug: [11C]AZ10419369

Effectiveness of a Cognitive and Physical Intervention to Reduce Head and Muscle Pain in a Large Population ClinicalTrials.gov Identifier: NCT01050972 Condition: Migraine; Tension Type Headache; Cervical Pain Interventions: Behavioral: Behavioral: Cognitive, Relaxation, Exercise Therapy

Pediatric Chronic Headache Trial ClinicalTrials.gov Identifier: NCT00389038 Condition: Headache Interventions: Behavioral: Coping Skills Training; Behavioral: Headache Education; Drug: Amitriptyline

Premium Migraine Trial ClinicalTrials.gov Identifier: NCT00355056 Condition: Migraine, Patent Foramen Ovale Interventions: Device: Amplatzer PFO Occluder; Device: Sham Device

Calcitonin Gene-related Peptide Levels in Chronic Migraine ClinicalTrials.gov Identifier: NCT01071096 Condition: Chronic Migraine Interventions: Drug: Botox; Drug: Placebo

Telcagepant for Prevention of Menstrually Related Migraine in Female Patients With Episodic Migraine ClinicalTrials.gov Identifier: NCT01125774 Condition: Migraine Interventions: Drug: Telcagepant; Drug: Placebo

Greater Occipital Nerve Block for Migraine Prophylaxis ClinicalTrials.gov Identifier: NCT00915473 Condition: Migraine Interventions: Drug: bupivicaine/methylprednisolone (Active Injection); Drug: Placebo Injection

PRIMA PFO Migraine Trial ClinicalTrials.gov Identifier: NCT00505570 Condition: Migraine, Patent Foramen Ovale Interventions: Device: Amplatzer PFO Occluder Device

Acupuncture for Migraine: a Functional Magnetic Resonance Imaging (fMRI) Study ClinicalTrials.gov Identifier: NCT01152632 Condition: Migraine Interventions: Manual Acupuncture

Cognitive Side Effects of Commonly Prescribed Medications in Pediatric Migraine ClinicalTrials.gov Identifier: NCT00777218 Condition: Migraine Interventions: Drug: propranolo9l; Drug: zonisamide; Drug: topiramate

Is Paraspinal Intramuscular Ropivacaine Injection an Effective Treatment for Headache in a Pediatric Emergency Department? ClinicalTrials.gov Identifier: NCT00680823 Condition: Migraine Interventions: Drug: Ropivacaine; Drug: Normal saline

Peer Mentorship: An Intervention To Promote Effective Pain Self-Management In Adolescents ClinicalTrials.gov Identifier: NCT01118988 Conditions: Irritable Bowel Syndrome (IBS); Functional Abdominal Pain; Fibromyalgia; Complex Regional Pain Syndrome (CRPS); Myofacial Pain; Chronic Daily Headaches; Migraine Headaches; Chronic Pain Interventions: Behavioral: Mentorship

Multicenter Study to Evaluate the Efficacy of DR-105 for Menstrually-Related Migraine Headaches ClinicalTrials.gov Identifier: NCT00781456 Condition: Migraine Interventions: Drug: DR-105; Other: Placebo

Acupuncture in Chronic Migraine: A Randomized Controlled Trial ClinicalTrials.gov Identifier: NCT01096420 Condition: Chronic Migraine Interventions: Procedure: acupuncture; Drug: topiramate

Study Evaluating a Novel Ibuprofen Formulation in Episodic Tension-type Headache ClinicalTrials.gov Identifier: NCT01077973 Condition: Episodic Tension-Type Headache Interventions: Drug: Novel Ibuprofen

NINDS CRC Chronic Migraine Treatment Trial ClinicalTrials.gov Identifier: NCT00772031 Condition: Migraine Interventions: propranolol LA; Drug: topiramate; Drug: placebo

A Study of a Melatonin Receptor Agonist to Prevent Migraine ClinicalTrials.gov Identifier: NCT00739024? Condition: Migraine; Migraine with Aura; Migraine without Aura Interventions: Drug: ramelteon

Does Treximet Improve Productivity and Patient Satisfaction Due to Sustained Response and Consistency of Response? ClinicalTrials.gov Identifier: NCT01086358 Condition: Workplace Migraine Treatment Interventions: Drug: Usual prescribed triptan; Drug: Treximet for Migraine treatment

Treximet for Prevention of Post Traumatic Headache Associated With Cognitive Dysfunction ClinicalTrials.gov Identifier: NCT01053507 Condition: Post-Traumatic Headache Interventions: Drug: sumatriptan/naproxen sodium; Drug: Placebo

The Identification and Characterization of Autonomic Dysfunction in Migraineurs With and Without Auras ClinicalTrials.gov Identifier: NCT01080287 Condition: Migraine Interventions: Drug: Naproxen; Drug: Sumatriptan; Behavioral: Migraine education;

Trial of Comprehensive Migraine Intervention ClinicalTrials.gov Identifier: NCT01071317 Condition: Migraine Interventions: Drug: Naproxen; Drug: Sumatriptan; Behavioral: Migraine education; Behavioral: Reenforcement of diagnosis; Other: Typical care

Intensive Meditation and Migraines: Effects on Health and Well Being ClinicalTrials.gov Identifier: NCT00663585 Condition: Chronic Daily Headache Intervention: Behavioral: Visassana Meditation

NINDS CRC Chronic Migraine Treatment Trial ClinicalTrials.gov Identifier: NCT00772031 Condition: Migraine Interventions: Drug: propranolol LA; Drug: topiramate; Drug: placebo

Influence of a Dietary Supplement as Treatment of Migraine in Children and Adolescents ClinicalTrials.gov Identifier: NCT01010711 Condition: Migraine Interventions: Dietary Supplement: Migra 3

A Study to Evaluate the Efficacy and Tolerability of Rizatriptan for Treatment of Acute Migraine in Children and Adolescents ClinicalTrials.gov Identifier: NCT01001234 Condition: Acute Migraine With or Without Aura Interventions: Drug: rizatriptan benzoate; Drug: Comparator: Placebo

A Randomized, Multicenter, Placebo-Controlled, Parallel Group Study to Evaluate the Efficacy and Safety of Oral Sumatriptan for the Acute Treatment of Migraine in Children and Adolescents ClinicalTrials.gov Identifier: NCT00963937 Condition: Migraine Interventions: Drug: Sumatriptan 50 mg; Drug: Sumatriptan 25 mg; Drug: Placebo

Pharmacokinetics and Safety of Intravenous Topiramate in Adult Patients ClinicalTrials.gov Identifier: NCT00753493 Condition: Epilepsy; Migraine Interventions: Drug: intravenous topiramate

A Multicenter Study to Evaluate the Efficacy of DR-105 for Menstrually-Related Migraine Headaches ClinicalTrials.gov Identifier: NCT00781456 Condition: Migraine Interventions: Drug: DR-105; Other: Placebo

Is Topiramate Effective in Treating Dizziness in Patient's With Migraine-Associated Dizziness ClinicalTrials.gov Identifier: NCT00732108 Conditions: Migraine; Headache; Dizziness Interventions: Drug: topiramate; Drug: lactulose placebo pill

Pilot Study to Compare Frovatriptan vs. Topiramate for Prevention of Migraine ClinicalTrials.gov Identifier: NCT00846495 Condition: Migraine Interventions: Drug: topiramate; Drug: frovatriptan

Rizatriptan 10 MG RPD in the Treatment of Acute Migraine ClinicalTrials.gov Identifier: NCT01057160 Condition: Migraine Intervention: Drug: Rizatriptan

Genetic Analysis of Children With Cyclic Vomiting Syndrome (CVS) and Migraines ClinicalTrials.gov Identifier: NCT00727974 Conditions: Vomiting Syndrome; Migraines

Effectiveness of a Cognitive and Physical Intervention to Reduce Head and Muscle Pain in a Large Population ClinicalTrials.gov Identifier: NCT01050972 Conditions: Migraine; Tension Type Headache; Cervical Pain Intervention: Behavioral: Behavioral: Cognitive, Relaxation, Exercise Therapy

A Randomized, Multicenter, Placebo-Controlled, Parallel Group Study to Evaluate the Efficacy and Safety of Oral Sumatriptan for the Acute Treatment of Migraine in Children and Adolescents ClinicalTrials.gov Identifier: NCT00963937 Condition: Migraine Interventions: Drug: Sumatriptan 50 mg; Drug: Sumatriptan 25 mg; Drug: Placebo

EP4-receptor Antagonism and Prostaglandin E2 (PGE2) in a Human Headache Model ClinicalTrials.gov Identifier: NCT00957983 Conditions: Headache, Migraine Intervention: Drug: BGC20-1531

A Pilot Study of Migraine and Appetite Behaviour in Children Conditions: Migraine Disorders; Obesity ClinicalTrials.gov Identifier: NCT00440518

Study of the Molecular Genetics of Menstrual Migraine ClinicalTrials.gov Identifier: NCT00904150 Conditions: Migraine; Migraine With Aura; Migraine Without Aura Intervention: Drug: ramelteon

American Migraine Prevention Study ClinicalTrials.gov Identifier: NCT00363506 Condition: Migraine Disorders Intervention: Behavioral: Serotona Plus and dietary behavior management

Clopidogrel For the Prevention of New Onset Migraine Headache Following Transcatheter Closure of Atrial Septal Defects ClinicalTrials.gov Identifier: CT00799045 Condition: Migraine Intervention: Drug: Clopidogrel

A Multicenter Study to Evaluate the Efficacy of DR-105 for Menstrually-Related Migraine Headaches ClinicalTrials.gov Identifier: NCT00781456 Condition: Migraine Interventions: Drug: DR-105; Other: Placebo

NINDS CRC Chronic Migraine Treatment Trial ClinicalTrials.gov Identifier: NCT00772031 Condition: Chronic Migraine Interventions: Drug: propranolol LA; Drug: topiramate; Drug: placebo

Investigation of Efficacy and Safety of Botulinum Toxin A (Botox-Allergan Inc) in Migraine Headaches ClinicalTrials.gov Identifier: NCT00660192 Condition: Refractory Migraine Interventions: Drug: Botulinum toxin A; Drug: Botulinum toxin A

Cognitive Side Effects of Commonly Prescribed Medications in Pediatric Migraine ClinicalTrials.gov Identifier: NCT00777218 Condition: Migraine Interventions: Drug: propranolol; Drug: zonisamide; Drug: topiramate

The Role of CGRP and Nociceptin in Migraine ClinicalTrials.gov Identifier: NCT00155129 Conditions: Migraine; Headache Intervention:

Migraine Inducing Effects and Changes in Brain Haemodynamics of PGI2 ClinicalTrials.gov Identifier: NCT00510172 Conditions: Headache; Migraine; Vasodilatation Interventions: Drug: Prostacyclin, PGI2; Drug: Placebo

Randomized Trial to Evaluate the Effectiveness of a Mindfulness Based Intervention (MBSR) for Patients Suffering From Migraine ClinicalTrials.gov Identifier: NCT00826475 Condition: Migraine Interventions: Behavioral: Mindfulness Based Stress Reduction MBSR; Behavioral: Psychoeducation

Oral Dexamethasone for Treatment of Migraine ClinicalTrials.gov Identifier: NCT00216736 Condition: Migraine Intervention: Drug: Dexamethasone

Efficacy of rTMS in the Treatment of Patients With Migraine ClinicalTrials.gov Identifier: NCT00316979 Condition: Migraine Intervention: Device: Repetitive Transcranial Magnetic Stimulation (rTMS)

Efficacy and Safety of BGG492 in the Treatment of Migraine ClinicalTrials.gov Identifier: NCT00892203 Condition: Migraine Interventions: Drug: BGG492; Drug: Sumatriptan; Drug: Placebo

Is Topiramate Effective in Treating Dizziness in Patient's With Migraine-Associated Dizziness ClinicalTrials.gov Identifier: NCT00732108 Conditions: Migraine; Headache; Dizziness Interventions: Drug: topiramate; Drug: lactulose placebo pill

Inflammatory Markers in Migraine - Ictally and Interictally ClinicalTrials.gov Identifier: NCT00868322 Condition: Migraine Headache Interventions: Drug: Treximet (Imitrex + naproxen sodium); Other: Inert Placebo

Randomized Evaluation of Octreotide Versus Compazine for Emergency Department Treatment of Migraine Headache ClinicalTrials.gov Identifier: NCT00274170 Condition: Migraine Headache Intervention: Drug: Octreotide

An Italian Open-Label Study of Occipital Nerve Stimulation in the Treatment of Chronic Migraine Headache ClinicalTrials.gov Identifier: NCT00407992 Condition: Headache, Migraine Intervention: Device: Neurostimulation

A Double-Blind Placebo-Controlled Trial of Rozerem in Migraine Headaches ClinicalTrials.gov Identifier: NCT00391755 Condition: Migraine Headache Intervention: Drug: ramelteon

Genetic Analysis of Children With Cyclic Vomiting Syndrome (CVS) and Migraines ClinicalTrials.gov Identifier: NCT00727974 Conditions: Vomiting Syndrome; Migraines Intervention:

A Research Study Examining The Use Of Duloxetine In The Prevention Of Migraine Headache ClinicalTrials.gov Identifier: NCT00443352 Condition: Migraine Intervention: Drug: Duloxetine

A Research Study Examining Migranal and Skin Sensitivity in Subjects With Migraine ClinicalTrials.gov Identifier: NCT00335777 Condition: Migraine Intervention: Drug: Migranal

Treatment of Acute Migraine Headache in Children ClinicalTrials.gov Identifier: NCT00355394 Condition: Migraine Headache Intervention: Drug: Metoclopramide

Treximet in Acute Migraine Headache: Assessing Cognitive Function ClinicalTrials.gov Identifier: NCT00837044 Conditions: Migraine Headache; Cognitive Impairment Interventions: Drug: Treximet; Drug: Migraine rescue medication of choice

Migraine and Recurrent Abdominal Pain in Children ClinicalTrials.gov Identifier: NCT00060619 Conditions: Migraine; Abdominal Pain Interventions: Behavioral: thermal biofeedback; Behavioral: relaxation training; Behavioral: cognitive coping skills; Behavioral: parent education

Is Paraspinal Intramuscular Ropivacaine Injection an Effective Treatment for Headache in a Pediatric Emergency Department? ClinicalTrials.gov Identifier: NCT00680823 Conditions: Headache; Migraine Interventions: Drug: Ropivacaine; Drug: Normal saline

Intensive Meditation and Migraines: Effects on Health and Well Being ClinicalTrials.gov Identifier: NCT00663585 Condition: Chronic Daily Headache Intervention: Behavioral: Vipassana Meditation

Orbitofrontal Cortex (OFC) Influence on Addictive Medication Overuse Headache (MOH) Deriving From Migraine ClinicalTrials.gov Identifier: NCT00833209 Condition: Medication Overuse Headache Interventions: Procedure: PET (withdrawal); Procedure: Imaging; Procedure: Imaging

A Research Study to Examine Cutaneous Allodynia and Cluster Headache ClinicalTrials.gov Identifier: NCT00329836 Condition: Cluster Headache Intervention: Drug: Migranal

Prophylactic Treatment of Episodic Cluster Headache ClinicalTrials.gov Identifier: NCT00184587 Condition: Cluster Headache Intervention: Drug: candesartan cilexetil (antiotensin II receptor blocker

Botulinum Toxin Injection in Neck Muscles in Cervicogenic Headache ClinicalTrials.gov Identifier: NTC00184197 Condition: Cervicogenic Heaqdache Intervention: Drug: Botulinum Toxin

A Pilot Study of Migraine and Appetite Behaviour in Children ClinicalTrials.gov Identifier: NCT00930852 Conditions: Migraine Disorders; Obesity

Pilot Study to Compare Frovatriptan vs. Topiramate for Prevention of Migraine ClinicalTrials.gov Identifier: NCT00846495 Condition: Migraine Interventions: Drug: topiramate; Drug: frovatriptan

Last updated October 8, 2010.