Diabetes, high estrogen increases dementia risk
Recent research published in the journal Neurology suggests that women who have diabetes combined with high estrogen levels may have a significantly increased risk of dementia.
To conduct their study, the research team from the French National Institute of Health and Medicine Research measured blood estrogen levels of 543 women aged 65 or over who were free of dementia, in addition to 132 women who had the disorder. All women were assessed for risk factors for dementia, including diabetes, high blood pressure and abnormal blood clotting, among other heart health risk factors.
The researchers found that women who had high estrogen levels were more than twice as likely to develop dementia, compared with women who had low estrogen levels. However, the researchers found that women who had both high estrogen levels and diabetes were 14 times more likely to develop dementia, compared with women without diabetes who had low estrogen levels. The research team also found that women with both dementia and diabetes had estrogen levels 70 percent higher than women who only had diabetes.
These results were surprising since previous research suggested that estrogen-based therapy may protect the brain.