Does Advair cause weight gain?

Health Professional

Weight gain while using Advair  is something that has been discussed a lot in asthma communities, as you can see here and here and here and here and here. Yet there has been very little documented evidence as to whether it is true or not.

I was recently asked, "Does Advair cause weight gain?"   My answer here  was a swift,  "Studies have shown that if you rinse your mouth out really well after using your Advair inhaler systemic side effects are very rare."

Yet considering the broad discussions on this topic, I'm now wondering if  my answer  was, perhaps, not quite complete.     Is it possible that Advair does cause weight gain, even with a good mouth rinse?

The answer:   it's possible. notes that while weight gain was not listed among the side effects of Advair during initial testing; many asthmatics on Advair have noted weight gain.

In fact,  more recently, weight gain has been added as a possible side effect as you can  see for yourself  in section 6.3 of this Advair insert.

Although it's mentioned under the following note:   "Because  (this side effect is)  reported voluntarily from a population of unknown size, estimates of frequency cannot be made."

So it's obvious there have been more than a few with the complaint of weight gain while using Advair.   At least enough to make weight gain worth noting under possible side effects.

Systemic corticosteroids, the kind given by IV or by mouth, can cause systemic side effects, including weight gain.   When I'm on them -- and thankfully I haven't needed them in over 10 years -- I get an insatiable appetite (yep, I'd eat my fries  and then finish yours too).   Weight gain was inevitable.

Yet, despite old fears, studies have shown inhaled corticosteroids, including Advair,  are safe, and side effects  rare,  so long as you rinse your mouth out.  And this is still true for the most part, and for most patients.

I know I have seen some websites note that the higher dose (500/50) of Advair has been linked to increased side effects, as compared with the lower doses (100/50 and 250/50).

So, this makes me wonder if I might  have been  correct, and perhaps all those folks complaining of Advair weight gain were either on the higher dose, or not rinsing their mouths out properly.

Still, for some reason that doesn't seem plausible.

Another consideration that might cause weight gain for some who take Advair, and this is listed as a possible side effect, is possible fluid retention  -- which may lead to weight gain.

Of course fluid retention is also a complication of illnesses such as heart and kidney failure, so if you have this then you ought to be calling your doctor to rule out other illnesses.

Only after other causes (including lack of activity) are ruled out can we start thinking that weight gain might be caused by a medicine such as Advair.

My coworker attended a class to prepare her for becoming an asthma educator a few years ago, and she learned studies showed being on a small amount of corticosteroid all the time (such as is provided by the daily use of Advair), is much safer than short bursts of corticosteroids.

So again, one must weigh the advantages of taking any medicine with the disadvantages.   In the case of Advair, and for most patients, the benefits far outweigh the disadvantages.

As far as my experience with weight gain and Advair, in the past (back in 2002) when I did the Body For Life diet I lost up to 40 pounds in one 12 week period. Yet recently (after gaining my weight back because I'm normal)  I only lost 20 pounds in 20 weeks. Now this could be age catching up to me, or the fact I didn't stick to the diet as well as I did in the past.

Yet -- and this idea crossed my mind --  it could be that I am now on Advair.

One of the advantages of Advair is  you only have to take it twice a day, which I usually do just prior to brushing my teeth in  the morning and at night.

In this way I don't miss doses like I used to. These results not only in better asthma control, but it also might increase my risk for side effects.

So, when I lost weight in 2002 I was not on Advair, I was using a Flovent inhaler and I often missed doses. Likewise, I did not use a spacer back then (a goofus perhaps?), which may have reduced the amount of corticosteroid in my system even further.

In essence, Advair improved my compliance and my technique, which results in better medicine distribution to my lungs. Could this possibly have also resulted in more side effects -- like weight gain?

Of course I am only speculating. Yet I know I'm not alone in thinking this way, as you can see by the discussions linked to above.

Some of us, however, may simply be trying to blame Advair for weight gain, when we should be blaming ourselves.  A good diet and exercise can help one maintain a good weight.   I'm not blaming the Advair, I'm just curious.

Still it would be neat to see further studies in this area.

That said I would never quit taking Advair. Never in my life had I had better asthma control than since I started this great medicine.

While side effects vary from person to person, and despite the warnings, they are still rare and minimal when they do occur.   I highly recommend you discuss with your doctor trying Advair if other medicines don't give you the results you yearn for.

So what do you think? What is your experience with Advair and weight gain? Are there studies  I'm not aware of? Discuss.