Drug Interactions With Methadone And Cymbalta


Asked by Ann Lenett

Drug Interactions With Methadone And Cymbalta

I have been taking cymbalta and methadone,neuerotinin,nambutone,metformin ,lasix, and glipiside,synthroid,acephix,k-Dur,. for many years. At my last visit with my pain management doctor, hhe said that he could no longer give me cymbalta and methadone as it was not safe. What do you reccommend instead?


Based on the fact that you have diabetes and thyroid problems, I would venture to guess that you also have a unhealthy, sensitive nervous system. Because your pain is maintained within the nervous system, it is easy to understand why Cymbalta and Methadone have worked well for you for years. Both Cymbalta and Methadone are special drugs that work for nerve pain.

Drug interactions are dose related, meaning it depends on how much your taking of both drugs. Without knowing your doses, it is hard for me to comment on the choice to change drugs.

Only two opioids are special enough to treat nerve pain: methadone and tramadol (Ultram, Ultram ER). So, your doctor should really consider Ultram if you need to move away from methadone.

Additionally, baclofen is a useful drug for nerve pain (just mention GABA to your doctor, that should mean something to him/her). Even though baclofen is a muscle relaxant, it works on the nerves also. Very cool!

Stay open minded and keep communicating with your doctor.

Dr. Christina Lasich, MD

Answered by Christina Lasich, MD