Can I Take Effexor Xr (225mg) With Zoloft (100mg) At The Same Time Safely?


Asked by Too many meds

Can I Take Effexor Xr (225mg) With Zoloft (100mg) At The Same Time Safely?

I have been taking both of these medications for years now. My new doctor however wants me try taking my Effexor XR 75 Mg which I usually took in the a.m. and the 150 Mg that I took before bed at the same time in the a.m. because I do not sleep through the night. I will sleep for a good 3-4 hours and then be wide awake. He seems to think that the Effexor XR may be the cause of this? Has anyone ever heard of this before? Also I did take Clonazepam 1Mg at bedtime and one of the same dosage in the am. Now I take both at bedtime which makes sense to me since it does cause drowsiness.

So......Should I be taking the Zoloft and Effexor XR at the same time in the a.m. or should there be a waiting period? I am always tired and this is why he wants to change my meds.


I agree that it sounds like your doctor is trying to help you have better sleep and more alert days. As far as Zoloft goes, the label suggests that it can be taken either in the morning or the evening, but always at the same time each day.

I take my Zoloft before I go to bed because my doctor told me when I first started that it could cause drowsiness or lethargy. I've read that for some people it disrupts their sleep, so they take it in the morning.

Perhaps you should continue taking the Zoloft at the same time you had been. This way you can isolate whether changing the time of day for Effexor and Klonopin does help relieve some of your tiredness during the day. Certainly if you have questions, ask your doctor who knows you best.

Answered by Lisa Emrich