Enbrel Stopped Working!!??!!??


Asked by sunshinegal43oh

Enbrel Stopped Working!!??!!??

I've been on Enbrel 9 weeks now. I noticed improvement in my inflammation and swelling after my second SureClick injection, and I've been feeling so much better that I thought Enbrel was a miracle drug.

I got off schedule, once. I normally take Enbrel on Saturday mornings. A couple of weeks ago I missed my Saturday deadline and took my injection of Enbrel late; but just by one day. I took the injection on Sunday morning instead of Saturday morning.

However, since that time, I've noticed that I'm not getting the great relief I was once getting. What does this mean? Does it mean that Enbrel has stopped working? Or does it mean I need a higher dose of the medication? I feel let down; I was feeling SO great- almost human again! And now I'm back to where I started.

Has anyone else had this happen?


one of the reasons that it seems as if Enbrel is not having the same kick as it used to may be that because you're feeling better, you're doing more. Even when your RA is well-managed, you still need to moderate your activity levels and work within your limits to ensure that you can do more the next day - check out my post on the Spoon Theory for more information about doing a bit less to in the long run do more.

You may also want to talk to your doctor about what's going on to check whether the Enbrel is not suppressing your RA as well as it used to. If not, you may need to increase your dose or supplement it with another medication, like a small dose of prednisone - in my experience, it can help take the Biologics from doing well to doing great. Combination therapy with other DMARDs (the disease modifying antirheumatic drugs like methotrexate, Plaquenil, etc.) may also get things working better.

Answered by Lene Andersen, MSW