Failed cancer drug restores memory in mice
A study at the Yale School of Medicine that tested a cancer drug on mice with Alzheimer’s has shown promise in restoring memory and connections between brain cells.
The drug had proven ineffective in treating solid cancer tumors, but when used in the research at Yale, it showed promise in blocking brain damage caused by the formation of amyloid-beta plaques, a hallmark of Alzheimer’s disease. The drug was able to restore brain connections and reduce inflammation, and the memory of the mice that was lost during the progression of the disease, returned.
The study was funded by a National Institutes of Health program to test failed drugs on different diseases. The next step will be to conduct trials to see how effective the drug may be in treating humans with Alzheimer’s.