Females could be more susceptible to effects of marijuana
In a new study published in the journal Drug and Alcohol Dependence, researchers from Washington State University found that women are more tolerant than men of tetrahydrocannabinol (THC), the main ingredient in marijuana. That means they may also be more susceptible to THC's negative side effects.
In testing the pain-relieving effects of THC in both male and female rats, the team found that after 10 days of treatment, females showed significantly greater tolerance to THC than the males, even after reducing doses by 30 percent.
Tolerance occurs when the subject's body gets used to THC so that larger and larger doses are needed to produce the same effects experienced with the first dose.
The researchers believe that a woman’s sensitivity to THC follows the fluctuation in hormones during her monthly cycle, thus increasing vulnerability to the negative side effects of THC, such as anxiety, paranoia and addiction.