Is There A Harmful Interaction Between Amiodarone And Ciprofoxacin Ie Cipro


Asked by Thomas Shoup

Is There A Harmful Interaction Between Amiodarone And Ciprofoxacin Ie Cipro

I have an infection in my leg that is showing some redness, I'm taking 200 mg of amiodarone and it was prescrided for me to take 500mg Cipro. I've had several heart attacks, and I have a difibulator. Is this cause for alarm?


Hi Thomas, thank you for your question.

According to our drug interactions information for amiodarone, this drug should not be used with the following medications because very serious interactions may occur:

  • agalsidase
  • dofetilide
  • certain HIV protease inhibitors (indinavir, nelfinavir, ritonavir, saquinavir)
  • quinupristin/dalfopristin

If you are currently using any of these medications, tell your doctor or pharmacist before starting amiodarone.

Other drugs besides amiodarone that may affect the heart rhythm (QT prolongation in the EKG) include other antiarrhythmics (e.g., flecainide, procainamide, quinidine, sotalol), macrolide antibiotics (e.g., erythromycin), pimozide, and quinolone antibiotics (e.g., levofloxacin), among others. Before using amiodarone, report all medications you are currently using to your doctor or pharmacist. QT prolongation can infrequently result in serious (rarely fatal) fast/irregular heartbeat and other symptoms (e.g., severe dizziness, fainting) that require immediate medical attention. Ask your doctor or pharmacist for more details and for instructions on how you may reduce the risk of this effect.

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of:

  • clopidogrel
  • certain "water pills" (potassium-wasting diuretics such as hydrochlorothiazide, furosemide)
  • drugs affecting liver enzymes that remove amiodarone from your body (such as azole antifungals including itraconazole, cimetidine, fentanyl, lidocaine, rifampin, St. John's wort, trazodone, certain anti-seizure medicines including phenytoin)

Amiodarone can slow down the removal of other drugs from your body by affecting certain liver enzymes. These affected drugs include (this is not a complete list): beta blockers (e.g., propranolol), calcium channel blockers (e.g., diltiazem, verapamil), cyclosporine, certain cholesterol-lowering "statins" (atorvastatin, lovastatin, simvastatin), digoxin, tizanidine, warfarin, drugs to treat erectile dysfunction (e.g., sildenafil, tadalafil, vardenafil).

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

Answered by Allison Bush