Imitrex Safety

by Dr. David Watson & Teri Robert Health Professional & Patient Advocate


How many days in a row can I safely take Imitrex? I take Imitrex 100 mg tabs. I'm trying to break up rebound migraines after taking Fioricet with codeine.

Also, how many days to I need to be off painkillers (mainly Fioricet) to stop this rebound cycle? Can I take plain Tylenol or Excedrin while I'm stopping the Fioricet and then try to wean off of those?

Imitrex and other triptan's side effects temporarily make symptoms worse for about 1-2 hours so I try to avoid it, but they always do cure the migraine. If necessary I will take imitrex.

I know the dangers of pain killers/NSAIDS, but I'm not sure about Imitrex. I worry about my liver and kidneys with all the Tylenol. I also take Zoloft 400 mg HS, Cymbalta 60 mg in morn, Neurontin 1200 mg, Lamictal 200 BID, Prazosin (for PTSD nightmares) 2mg HS and Seroquel.

A couple wks ago I received an injection of Lupron for endometriosis and started Progesterone tabs 5mg in a.m. I will get one more injection in about 3 months so total duration of treatment will be 6 months. Verapamil didn't do anything and doesn't help my brother either.

Migranol doesn't help. Propranolol made my anxiety worse. I've been on Topomax, but I can't remember why I stopped it or if it had an adverse reaction.

I have no choice on psych meds because I'm bipolar with history of psychosis (only once 6 years ago). I appreciate any recommendations. Thx - Andrea.


Dear Andrea,

It's not the number of consecutive days that medications are taken that is important, but how many days in a week acute medications are taken. Most experts agree that the total number of days per week that ALL acute medications combined be taken is no more than two or three.

Take a good, careful look at this article, Medication Overuse Headache: When the Remedy Backfires, and make special note of this section:

8.2.6 Medication-overuse headache attributed to combination of acute medications

Intake of any combination of ergotamine, triptans, analgesics and/or opioids on 10 or more days/month on a regular basis for more than 3 months without overuse of any single class alone.

As you can see from that, taking Imitrex for a couple of days and another acute medication for a couple of days - even something as simple as acetaminophen - can cause medication overuse headache (MOH) or keep you from getting out of a medication overuse cycle. Fioricet is especially problematic when it comes to MOH because any of the ingredients in it can cause MOH by themselves, so when you combine them, you get a triple whammy. Excedrin is the same way.

When having problems getting out of an MOH cycle, one of the most beneficial things you can do is ask your doctor for assistance.

Good luck,
John Claude Krusz and Teri Robert

Dr. David Watson & Teri Robert
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Dr. David Watson & Teri Robert

Do you have questions about Migraine? Reader questions are answered by UCNS certified Migraine and headache specialist Dr. David Watson, and award-winning patient educator and advocate Teri Robert.