Can You Take Ibuprofen With Prednisone?


Asked by susie

Can You Take Ibuprofen With Prednisone?


Hi Susie,

This would be an great question for your pharmacist. There may be other factors involving your current health, medical history, or use of medications which could influence the answer FOR YOU.

According to the drug interaction tool at, there is a moderate interaction risk when taking a steroidal drug such as prednisone and a nonsteroidal anti-inflammatory drug such as ibuprofen. Seems that the most common risk would be related to gastrointestinal problems, including inflammation, bleeding, ulceration, and perforation.

If you have a history of ulcers or bleeding GI problems, then you should certainly demonstrate caution when taking a drug such as ibuprofen. Talk to your doctor and pharmacist please.

Answered by Lisa Emrich