Migraine Term of the Day - CGRP

Patient Expert

migraine glossaryWriter's note: Some of you have expressed an interest in learning more of the medical terminology that comes up when discussing migraine disease and other headache disorders. So, I'll be posting a "term of the day," on a regular basis. If there are terms you'd like to have defined, please leave a comment below.

When we're given migraine and headache information, whether from our doctor, a book, or an online article, we sometimes come across medical terms that can be confusing. While it's easy enough to substitute another word or a short phrase for the medical term, there are times when substituting doesn't quite convey the same meaning.

CGRP is one of those terms. We're hearing a great deal about CGRP because there are several new migraine medications in development that impact it, so it's an important word for migraineurs to understand.


CGRP is an acronym for** calcitonin gene-related peptide**. It's an amino acid peptide that is naturally produced by our bodies.

Here's an example of how it's used in a sentence:** CGRP** has been implicated in the pathogenesis of migraine — where and how migraine originates and develops in our bodies.


Research into CGRP antibody medications is the most exciting development in the treatment of migraine in decades. As of November, 2016, four pharmaceutical companies have CGRP drugs in clinical trials, some for acute treatment and some for preventive. If these drugs succeed in clinical trials and receive FDA approval, they will be the only medications available that were actually developed for the prevention of migraine.

For more terms, see our Migraine Medical Terms Glossary Index.