Nasal spray may replace pills for brain disorders
Medicine delivered through a nasal spray may be more effective in treating brain disorders than traditional oral medications, suggests new research from Denmark.
Based on previous studies scientists have found that because pills are a particularly inefficient way to get medication to the brain, patients are often given high dosages, and that can result in negative long-term side effects. So researchers have instead attempted to deliver drugs through the nasal wall, but have struggled with finding an effective way for the medication to be released once it got to the brain.
In the new study, scientists from University of Southern Denmark and Aalborg University tested the effectiveness of a drug delivery vehicle made up of a natural sugar polymer. Once they created the delivery vehicle, the researchers tested whether they could deliver drugs through the nasal wall to the brain in the form of a nasal spray.
The nasal spray proved successful in that it provided solutions to two out of the three major roadblocks to making nasal sprays work. It was able to both deliver drugs through the nose as well as get the drugs to release once they entered the brain. Researchers said that the remaining challenge is find a way to steadily supply brain drugs over a long period of time.