New Guidelines for Mild-to-Moderate Ulcerative Colitis Treatment


The American Gastroenterological Association has published new clinical guidelines for treating mild-to-moderate ulcerative colitis (UC), an inflammatory bowel disease (IBD). Mild-to-moderate UC, characterized by periods of disease activity followed by periods of remission, is defined by these symptoms:

  • Fewer than four to six bowel movements per day
  • Mild or moderate rectal bleeding
  • Absence of symptoms like fever, fatigue, weight loss, or malaise
  • Low, rather than high, levels of inflammatory activity

The new guidelines, published in Gastroenterology, focus on the use of oral and topical 5-aminosalicylates (5-ASA) medications (sulfasalazine, mesalamine, balsalazide, olsalazine), rectal corticosteroids, and oral budesonide (Entocort EC, Uceris). People with ulcerative colitis who don’t respond to these therapies may require a stronger medication regimen, but the new guidelines don’t address these treatments.

Sourced from: Gastroenterology