Researcher at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Medicine in Baltimore say they’ve developed a single blood test that can detect eight types of cancer and help identify the location of the disease.
Called CancerSEEK, the test is unique and noninvasive. It simultaneously evaluates blood levels of eight cancer proteins and detects cancer gene mutations from circulating DNA. According to the researchers, the test can be used to screen for cancer of the ovary, liver, stomach, pancreas, esophagus, colon and rectum, lung, or breast – diseases that account for more than 60 percent of cancer deaths in the United States. There is currently no screening test for ovarian, liver, stomach, pancreatic, and esophageal cancers.
Johns Hopkins researchers evaluated CancerSEEK in a clinical trial involving 1,005 patients with stage I or stage II cancer. The overall ability of the test to detect cancer was 70 percent, and sensitivity ranged from a high of 98 percent for ovarian cancer to a low of 33 percent for breast cancer. These findings were published in Science. Larger studies of the test are now underway.