Obesity in Midlife May Increase Risk of Early Alzheimer's
People in mid-life who are overweight or obese may be at an increased risk of early onset Alzheimer’s disease, according to new research from the National Institute of Aging.
For their study, researchers analyzed 1,394 cognitively healthy adults who were part of the Baltimore Longitudinal Study of Aging (BLSA).
The team evaluated the participants’ body mass index (BMI) at age 50 – the midlife marker – and their development of Alzheimer’s with a series of neurological assessments every two years for 14 years. During follow-up sessions, 142 participants developed Alzheimer’s.
Their findings, published in Molecular Psychiatry, showed that participants who were overweight or obese in midlife – a BMI of 25 or over – were more likely to develop Alzheimer’s around 6.7 months sooner than participants at a healthier weight.
Additionally, the risk of Alzheimer’s rose with each unit increase in midlife BMI. For instance those with a BMI of 30 at age 50 were more likely to develop Alzheimer’s a year earlier than those with a BMI of 28 at age 50.
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