Pain Relievers Linked to Heart Failure
According to a study published in The BMJ, prescription and over-the-counter nonsteroidal anti-inflammatory drugs (NSAIDs), which are used to treat pain and inflammation, increase the risk for heart failure. Because of these findings, the European Society of Cardiology now recommends that people at high risk for developing heart failure should limit their use of NSAIDs, and people with the condition should avoid the drugs completely.
For the observational study, researchers assessed information from health care databases in Germany, Italy, the Netherlands, and the United Kingdom. More than 10 million NSAID users and 8 million controls were included in the data. A total of 27 NSAIDs, including four COX-2 inhibitors, were studied.
According to researchers, people who used an NSAID within the past two weeks were 19 percent more likely to be admitted to the hospital with heart failure than those who had not used an NSAID for at least 183 days. Drugs associated with an increased heart failure risk include diclofenac, ibuprofen, indomethacin, ketorolac, naproxen, nimesulide (This drug is not on the FDA’s approved list of NSAIDs.), and piroxicam, as well as the COX-2 inhibitors etoricoxib and rofecoxib.
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