Risky Drug Combinations

One in six older adults are at risk of a major drug-drug interaction. That’s when one drug affects the way another one works. Potential adverse effects range from kidney failure to heartbeat irregularities. Here are some dangerous combinations to avoid:

• Amlodipine and simvastatin—risk of nerve damage, muscle injury, kidney failure

• Warfarin and simvastatin—risk of bleeding, muscle damage, kidney failure

• Aspirin and clopidogrel bisulfate—risk of bleeding

• Aspirin and naproxen—risk of bleeding, ulceration, perforation

• Clopidogrel bisulfate and omeprazole—risk of serious blood clots

• Niacin and some statins—risk of nerve damage, muscle injury, kidney failure

• Lisinopril and potassium—risk of hyperkalemia (a buildup of potassium that can cause heartbeat irregularities)

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HealthAfter50

HealthAfter50 was published by the University of California, Berkeley, School of Public Health, providing up-to-date, evidence-based research and expert advice on the prevention, diagnosis, and treatment of a wide range of health conditions affecting adults in middle age and beyond. It was previously part of Remedy Health Media's network of digital and print publications, which also include HealthCentral; HIV/AIDS resources The Body and The Body Pro; the UC Berkeley Wellness Letter; and the Berkeley Wellness website. All content from HA50 merged into Healthcentral.com in 2018.