Risky Drug Combinations

One in six older adults are at risk of a major drug-drug interaction. That’s when one drug affects the way another one works. Potential adverse effects range from kidney failure to heartbeat irregularities. Here are some dangerous combinations to avoid:

• Amlodipine and simvastatin—risk of nerve damage, muscle injury, kidney failure

• Warfarin and simvastatin—risk of bleeding, muscle damage, kidney failure

• Aspirin and clopidogrel bisulfate—risk of bleeding

• Aspirin and naproxen—risk of bleeding, ulceration, perforation

• Clopidogrel bisulfate and omeprazole—risk of serious blood clots

• Niacin and some statins—risk of nerve damage, muscle injury, kidney failure

• Lisinopril and potassium—risk of hyperkalemia (a buildup of potassium that can cause heartbeat irregularities)

Meet Our Writer

HealthAfter50 was published by the University of California, Berkeley, School of Public Health, providing up-to-date, evidence-based research and expert advice on the prevention, diagnosis, and treatment of a wide range of health conditions affecting adults in middle age and beyond. It was previously part of Remedy Health Media's network of digital and print publications, which also include HealthCentral; HIV/AIDS resources The Body and The Body Pro; the UC Berkeley Wellness Letter; and the Berkeley Wellness website. All content from HA50 merged into Healthcentral.com in 2018.