Sandomigran (Pizotifen)


Asked by May

Sandomigran (Pizotifen)

I am currently taking one Sandomigran (Pizotifen) each night, it used to make me quite drowsey. However, I am now getting migraines every day. I have only been on the medication for about three weeks. I have a doctors appointment but that is still two weeks away. I was wondering if there was anything I should be asking my doctor specific for. Is there any other medications that I might be advisable to take. The first medication I was given was Endep 10, it was working really well except that I was gaining weight. Is there something similar to the Endep 10 that I can take? I realise I cant specifically narrow down which component that was causing me to gain weight.



Hi May!

Sandomigran is one of many medications used to help prevent Migraine attacks. It's not available in the U.S., and is one of the medications used less frequently. Right now, there are over 100 Medications currently being used to prevent Migraine See: Migraine Preventive Medications: Too Many to Give Up! As with other medications, it IS possible that it could be making your Migraines worse rather than better. Definitely discuss this issue with your doctor.

Endep is a tricyclic antidepressant (amitriptyline), and unfortunately weight gain is a potential side effect of that class of medication. Dr. Krusz, our Ask the Clinician, calls tricyclics "primitive" and no longer prescribes them. You might want to discuss EffexorXR with your doctor. It's an SNRI, an antidepressant that works on both serotonin and norepinephrine and has been effective as a Migraine preventive.

Being that you state you've only been on the Sandomigran for three weeks, it may be too soon to tell if it is working for you Migraine prevention. Typically, it can take up to three months to see if a medication is working or not.

Are you currently using anything to treat a Migraine attack, such as an abortive? See Preventive, Abortve, and Rescue Medications: What's the Difference? It may also be helpful to keep a Migraine and Headache Diary, to help you better track your Migraines. This is a very beneficial tool when talking with your doctor.

Good Luck!

Eileen Gray