In a mouse study supported by the National Institutes of Health (NIH) and the Veterans Administration, researchers at the University of Alabama at Birmingham reversed wrinkles and hair loss resulting from impaired cell function in mouse models.
For the study, the researchers gave the mice an antibiotic called doxycycline to induce a genetic mutation that caused mitochondrial parts of cells to malfunction and led to signs of aging – hair loss, slowed movements and lethargy, and wrinkled skin – within a matter of weeks. Mitochondria are found in all cells except red blood cells and are responsible for creating more than 90 percent of the energy needed to support organ function and sustain life. When the researchers discontinued the drug and mitochondrial function was restored, the mice’s appearance returned to normal, with smooth skin and thick fur.
In humans, mitochondrial function declines with age and contributes to age-related diseases, like heart disease, diabetes, neurological disorders, and cancer.
Sourced from: Cell Death & Disease