For the first time, scientists have been able to create a miniature version of a stomach from human stem cells.
Researchers from Cincinnati Children’s Hospital Medical Center were able to get mature human cells that have the ability to change into any cell type to grow into a miniature human stomach, or “gastric organoids.” Before creating the organ, the scientists spent years studying how the stomach is formed during embryonic development.
One month after researchers applied the stomach-formation processes to stem cells in a petri dish, the 3-D human gastric organoids were formed.
The researchers have used the organoids to study bacteria known to cause peptic ulcer and stomach cancer. Within 24 hours of introducing the bacteria into the miniature stomach, they saw that biochemical changes occurred, ones that reflected early stages of gastric disease.
The researchers believe the development could be a big step forward in understanding how conditions and diseases develop in the stomach.