SPF30 Sunscreens Delay Melanoma
Some timely news as beach, lawn care and gardening season approaches …
Researchers at The Ohio State University Comprehensive Cancer Center, Arthur G. James Cancer Hospital and Richard J. Solove Research Institute have developed a mouse model that allows them to test the ability of a sunscreen to not only prevent burns but also to prevent or delay melanoma.
In the lab, genetically engineered mice spontaneously develop melanoma about 26 weeks after the chemical 4-hydroxytamoxifen (4OHT) is applied to the skin. The study team found that if they exposed the genetically engineered mice to a single dose of UVB light one day after applying 4OHT to the skin, melanomas appeared much more rapidly, and there were many more tumors.
The researchers then used this mouse model to test the ability of a number of sunscreens labeled SPF30 to prevent melanoma. The sunscreens, which contained a range of UV-blocking agents, were applied to the mice prior to exposure to the UVB light. All the sunscreens delayed melanoma onset and reduced tumor incidence.
The hope is that this information can be used to develop smarter sunscreens that are both safe to use and proven effective in reducing skin cancer risk. And perhaps most importantly, these findings suggest that the mouse model can be used to identify new, more effective melanoma-preventing agents.