Study Shows Ovarian Cancer May Originate Elsewhere
Some researchers have suspected that the most common type of ovarian cancer – high grade serous ovarian tumors – may actually originate in the fallopian tubes, rather than the ovaries. Now, a small study conducted by researchers at the Johns Hopkins Kimmel Cancer Center in Baltimore and the Dana Farber Cancer Institute in Boston suggests this may indeed be the case.
This new discovery could lead to new ways to prevent and treat ovarian cancer, which is the fifth leading cause of cancer deaths in women. Ovarian cancer is often diagnosed late, and the disease carries a poor prognosis. Fewer than 30 percent of women with ovarian cancer survive beyond 10 years after diagnosis.
For this recent study, researchers collected tissue samples from five women diagnosed with ovarian cancer. The samples included normal cells, ovarian cancer cells, metastatic cancer cells, and cancer cells found in the fallopian tubes. Through genetic testing, the researchers then determined that each woman’s cancer originated in the fallopian tubes. Results of this study were published in Nature Communications.