Asthma-like symptoms were recorded in the earliest forms of writings going all the way back 5,000 years.
With all that history,
it's hard to believe we only recently started coming
up with viable
to why some people develop asthma.
My favorite guess is the hygiene hypothesis.
The ancient Romans found a link between cleanliness and disease, and created aquaducts to supply clean water and bath houses to give people a place to wash up. When bacteria were discovered in the 1800s, the Roman's were proven correct.
Since the discovery and understanding of how germs cause disease, there has been an effort by society to stay clean.
But is it possible that we have become so clean that we have opened ourselves up to suffering new kinds of diseases?
Is it possible that
civilization causes asthma?
According to the Hygiene Hypothesis, the
answer is yes.
speculated that the same things that trigger acute asthma attacks are the same things that cause asthma.
In that sense, many scientists looked at pollution as a main cause. Asthma rates increased by 75% between 1980 and 1995. Most asthma deaths (80.2% according 1989 stats) occured in highly populated
urban areas as well.
However, while pollution has been proven to "trigger" asthma, other studies
show that in areas where pollution levels are decreasing asthma rates are still on the rise.
This research encouraged
David P. Strachan
to look in a unique direction.
He made an observation that in Third World nations where people lived in poverty,
on farms, and were rarely innoculated from infectious disease, asthma rates were lower than in developed nations like the U.S., Europe and Australia with high concentrations of the population living in urban areas and high rates of childhood vaccination.
He also observed that the same pollution and allergens that exist where asthma rates are low also exist in places where asthma rates are high.
proposed the Hygiene Hypothesis in the
British Medical Journal
This hypothesis, or educated guess, is that the asthma gene is not turned on because we are too dirty, but because we are too clean. He came to this conclusion after looking at studies
people who live near farm animals were less likely to develop asthma.
Since people in many Third World nations work in farming or are often around animals, they are exposed to bacteria and parasites common around these animals.
Likewise, studies revealed
people exposed to pig and cattle parasites and bacteria in the first three months of life
(when their immune system is still developing)
were less likely to get asthma. According to The Medical College Of Wisconsin, these studies and observations
"led several researchers to conclude that organisms in cattle dust and manure may be the stimuli that their immune systems needed to fight off asthma."
several studies (like this one)
showed that children
exposed to pet dander (proteins in pet saliva and skin, but not pet hair) were
This seems counterintuitive, since it is common (and correect) advice for people and children with asthma and allergies to either get rid of their pets or to, at least, keep them out of the bedroom and off the furniture.
So why would this be?
Consider this: asthma is an autoimmune disease.
When we are born, our immune systems are still developing. Considering that our immune system doesn't fully mature until we are about 3 months old, it is prior to this time
that something "might" occur to turn the so-called asthma gene on -- if a person has the asthma gene.
The hygiene hypothesis surmises that if we are not exposed to certain bacteria and parasites for our immune systems
to battle, our immune systems get "bored" and may, instead, react to and create antibodies against normally harmless substances such as pollen and dust, i.e. allergens.
Once the asthma gene is turned on, you, more than likely, will have asthma.
people will notice asthma symptoms in childhood as they are exposed to their asthma triggers.
However, many others
will have symptoms so mild during childhood they won't even realize they have it until they are adults (adult onset asthma).
Per this hypothesis, there are people that may be at higher risk of developing asthma as well as events more likely to trigger its development, such as:
However awkward this sounds, it
all makes sense to me.
What do you think?