Topamax has stopped working, now getting side effects. Suggestions?

Health Professional

Full Question:

Hi, Is it possible that after being on Topamax for over 10 years that it is not longer effective and should I consider going off the drug for a while or permanently? Changing the dosage isn't even working anymore, the migraine intensity have become so much more severe in the last year that I believe it's just not working anymore. After reading so many migraineurs' problems with Topamax I feel pretty lucky but I think the luck has run out and the terrible side effects have finally hit me. Any suggestions for those of us who have had long term use of this drug? Diane.


Dear Diane;

It is possible for a medication to become ineffective for you after a period of time. In such cases, the medication might work again if you take a break from it, or it may not. There's no way to predict that.

There are two options here:

  • Work with your doctor to get off the Topamax and try it again in several months.
  • Work with your doctor to get off the Topamax and try a different medication.

There are many choices of medications for Migraine prevention. You can find a list of possible preventives, including medications in the same family as Topamax, in Migraine preventive medications: too many options to give up!

If your doctor isn't able to help you, it may well be time to consult a Migraine and headache specialist. It's important to note that neurologists aren't necessarily Migraine and headache specialists. Take a look at the article  Migraine and Headache Specialists - What's So Special? If you need help finding a Migraine specialist, check our listing of ** Patient Recommended Migraine and Headache Specialists**.

Good luck,
John Claude Krusz and Teri Robert

To review other questions from our Ask the Clinician Column,

_browse the Ask the Clinician archives _.

If you need help finding a   Migraine and headache specialist,

visit our listing of _Patient Recommended Specialists _.

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