Asked by colddigits
Can You Take Tramadol With Hydromorphone?
The Drug Interactions Checker on Drugs.com basically says "No". This combination of drugs is one of the few combinations that I've seen that has 'major' interactions. The problem is that taking these drugs together can increase the risk of seizure. Drugs.com recommends that a different combination of drugs be used. Here is what they say.
GENERALLY AVOID: Concomitant use of tramadol increases the seizure risk in patients taking other opioids. These agents are often individually epileptogenic and may have additive effects on seizure threshold during coadministration. CNS- and respiratory-depressant effects may also be additive. In patients who have been previously dependent on or chronically using opioids, tramadol can also reinitiate physical dependence or precipitate withdrawal symptoms.
MANAGEMENT: Concomitant use of tramadol and other opioids should be avoided in general. Tramadol should not be used in opioid-dependent patients, and use in patients who are chronically on opioids is also not recommended. Tramadol is contraindicated in patients with acute opioid intoxication. Tramadol dosage should be reduced if it must be used in patients receiving opioids. Patients should be monitored for development of seizures and CNS and respiratory depression.