What Is The Difference Between Arb's And Ace Inhibitors?


Asked by dsj

What Is The Difference Between Arb's And Ace Inhibitors?


Hi dsj,

ACE Inhibitors (Angiotensin-Converting Enzyme Inhibitors) act within the kidney's. The kidney's produce renin. Renin is converted to angiotensis-I on into angiotensis-II. Angiotensin-II is a powerful vasoconstrictor (causes your blood vessel diameter to be smaller). Angiotensin-II also secretes aldosterone, which holds water and sodium in the kidneys instead of excreting them. This leads to increased blood volume and high blood pressure. ACE Inhibitors prevent the conversion of angiotensin-I to angiotensin-II.

ARB's (Angiotensin II Receptor Blockers) also work within the kidney. ARB's prevent angiotensin-II from binding to its' receptor site, preventing blood vessel constriction and the secretion of aldosterone.

ARB's are a newer class of high blood pressure medication and tend to be better tolerated. However, it's best to work with your MD to determine the appropriate medication for your treatment.

All the best,

Lisa Nelson, RD, LN

You should know: The answer above provides general health information that is not intended to replace medical advice or treatment recommendations from a qualified healthcare professional.