What Is The Difference Between Neoadjuvant Treatment And Adjuvant Treatment ?

Question

Asked by zahia

What Is The Difference Between Neoadjuvant Treatment And Adjuvant Treatment ?

On the August 12 , 2009 I was diagnosied with a Suspicious mass in my right breast

I did a biopsy the 28 August 2009 , and till now I didn't bigin my treatment.

So I have ,

-- DUCTAL INVASIVE CARCINOMA, Nuclear GRADE 3/3(E CADHERIN positive)

IN-SITU DUCTAL CARCINOMA COMPONENT NOTED, Nuclear GRADE 3/3

WITH CENTRAL COMEDO-TYPE NECROSIS.

-- SURROUNDING BREAST SHOWS CHANGES CONSISTENT WITH PSEUDOANGIOMATOUS

STROMAL HYPERPLASIA, COLUMNAR CELL CHANGES AND MILD CYSTIC CHANGES.

-- Also, I have ER POSITIVE with % of cells positive: 95 -

Staining intensity :moderate and strong

Antibody used : SP1

ER POSITIVE with % of cells positive: up to 10-

Staining intensity : weak, moderate and strong

Antibody used : 1E2

HER2/neu Protein : NEGATIVE

Score : 0

Antibody used : 4B5

My Doctor for surgery suggested two treatment options, neoadjuvant or adjuvant.

My rumor is in my right breast, and is 20 mm X 16 MM , can anybody help me about

what are the risks and benefits between the two options ? I know that my surgeon

want to shrink the tumor, but is this the best way to get rid of it ? and how many

times I will go through the chimiotherapy treatment ? does anybody know about someone

who did the same treatment ( I mean Neoadjuvant treatment ) ?

. Can you tell me the difference and the risk factors about them ?

Thanks for you help

zahia

Answer

Hi - Neoadjuvant and adjuvant simply refer to "before surgery" and "after surgery." Neoadjuvant treatment means chemo before surgery; adjuvant means chemo after surgery. Studies have shown various results for giving chemo before vs. after surgery; so at this point it's inconclusive whether one or the other is better. If I were you, I'd trust my oncologist's decision. If s/he wants you to do chemo prior to surgery, to shrink the tumor and make the surgery easier/more effective - why not do it?

As for what chemo will be like, this is a question for your doctor. It'll be based on all the details of your pathology report, and the doctor's best guess as to what will work well, drug-wise and schedule-wise. So best to ask him/her, OK? Good luck - PJH

Answered by PJ Hamel