Are You at Risk for Rheumatoid Arthritis?

Patient Expert

Who gets rheumatoid arthritis (RA)? Could you get it?

What is RA?

RA is a systemic autoimmune disease that affects approximately 1 percent of the population. In autoimmune diseases, the immune system malfunctions and starts attacking the body’s own cells. In RA, this affects the joints and other systems in the body, such as internal organs, tendons, and the vascular system.

We still don’t know what causes RA, although researchers are beginning to identify environmental and lifestyle factors that may contribute to the immune system process triggering the development of RA in people who are genetically predisposed.


A variation in a genetic marker called human leukocyte antigen, especially HLA-DR4, can make someone susceptible to developing RA. It is only one of the genes that has been identified as being linked to RA. Research in this area continues.

If one of your family members has the disease, you have an increased risk of developing it, too. Many people are concerned about possibly passing RA on to their children. If you come from a family where your mother and grandmother both had RA, it may be more likely. However, the average risk of a first-degree relative (child or sibling) having RA is less than 20 percent.

Gender and age

Gender is a factor in who gets RA. Women develop the disease three times more often than men. This seems to indicate that hormones may play a role in the development of the disease. Other factors also point in this direction. Women tend to get RA in childbearing years, between the ages of 30 and 60, whereas men tend to get RA later in life. As well, in pregnant women with RA, up to 70 percent experience remission while pregnant, although the disease tends to come back about six weeks after the birth of the baby.

Environmental risk factors

One of the most exciting developments in recent years is more insight into the pathogenesis of RA — that is, what causes RA to develop. Research indicates that it is a mix of genetics and environmental risk factors. Some of these factors include smoking, periodontal disease, and micro-bacteria in the gut. The latter is especially intriguing, with some evidence of a link between a particular micro-bacteria called Clostridium and arthritis, but the dynamics of how this process occurs is still not known.

Environmental risk factors are also thought to be the potential culprits behind a recent rise in RA in women. study looked at over 50 years worth of epidemiological data and found the rate of RA in women rose 2.5 percent per year in the period from 1995 to 2007. The authors of the study speculated that the environmental factors contributing to this rise include smoking, vitamin D deficiency, and lower-dose synthetic estrogen in birth control.

Predicting RA

Given all this information, is it possible to predict who will develop RA?

Unfortunately, the answer is a resounding not really. With one exception. A newer blood test called the anti-CCP (or anti-cyclic citrullinated peptide) measures an antibody that has been connected to RA. This test is much more accurate than previous blood tests and can also be positive up to 15 years before a person develops RA. This has given researchers an intriguing challenge: to find a way to stop the condition before it becomes active. Some believe that it will soon be possible to find a way to turn off RA before it starts in such individuals.

My thoughts: Having lived with this disease for over 40 years, I can honestly say that now is an incredibly exciting period in RA research. So many new discoveries are made every year and there is so much hope for the future. I never used to think that I would see medications like the biologics, and yet, here they are. Now I truly believe that we will see a cure in my lifetime.

See more helpful articles:

Cause of Rheumatoid Arthritis May Be Bacteria in the Gut

What Is New with Rheumatoid Arthritis: Langone Medical Center Webinar

Facts about Vitamin D and Rheumatoid Arthritis

How Do Biologics Treat RA?

Rheumatoid Arthritis and Pregnancy