Why Does Actos Cause Weight Gain?


Asked by Faye

Why Does Actos Cause Weight Gain?


Most drugs for diabetes, including Actos and its sister drug Avandia, cause weight gain.

Actos and Avandia are insulin sensitizers. They sensitize the cells to the insulin so that the cells can more efficiently take up the glucose. This means that when people have an excessive caloric or carbohydrate intake, they would need more insulin to metabolize the glucose load. When the insulin resistance is reduced, the insulin will effectively move the glucose needed for energy into the cells and also efficiently allow the excess to be stored as fat. If they eat too much, the pancreas will make more insulin, and because they are not insulin resistant, what they do not use for energy will be efficiently stored as fat -- which is how we all gain weight with or without diabetes. So Actos and Avandia can cause weight gain, because insulin is now working efficiently and the excess will be stored as fat.

It is the insulin that your body produces that makes you hungry. When you are hungry, you naturally eat more.

I wrote about this issue at


Best regards,

David Mendosa


Answered by David Mendosa