Why brain tumors are more common in men
New research from Washington University School of Medicine in St, Louis has found an explanation for why brain tumors are more common men.
The researchers aimed to identify reasons for differences in male versus female brain cells by carrying out experiments that evaluated RB, along with two other genes--neurofibromin and p53--that normally suppress cell division and cell survival. In may types of cancers, these genes are found to be mutated and disabled.
The findings, published in the Journal of Clinical Investigation (JCI), showed that the RB gene was more likely to be inactivated in male brain cells than in female brain cells, which may explain why men are more susceptible to brain tumors, as the RB gene is known to reduce cancer risk.
The study provides researchers with better understanding of the mechanisms by which cancer works to develop and spread, which may help them develop more effective therapies and perform targeted clinical trials.