"Sometimes you don’t notice any difference for several weeks," says Molly Schreiber, 39, who has RA and type 1 diabetes and lives in Baltimore. "I initially thought I would notice change the next day." And Emil DeAndreis, 34, has learned that his symptom improvement, even after 10 years, is still gradual after an injection: "Maybe a couple days later, I feel my joints start to loosen up, and my morning stiffness is a bit milder," says DeAndreis, who lives in San Francisco.
Both experiences are totally normal, says rheumatologist Michael George, M.D., of Penn Medicine in Philadelphia. It might take your body time to respond to treatment, and that's ok.