Fatigue is one of the most common symptoms of multiple sclerosis (MS)—affecting about 80 percent of those living with the disease. Fatigue is more than tiredness and can become overwhelming. It interferes with your ability to get things done and may zap your energy so you can’t do what you really want to do. Fatigue can make it hard to put thoughts together or may make you feel like you’re dragging around concrete blocks. Without a doubt, fatigue can easily derail your daily activities.