Many RA meds have one side effect in common: they can make your gastrointestinal system very unhappy. Acid reflux or GERD can make it feel as if there's a roiling vat of acid burning up your mid-region. Then there's nausea, bloating, gas and constipation or diarrhea that can feel very similar to Irritable Bowel Syndrome (IBS). Speak to your doctor about your symptoms. If they seem to be side effects of your medications most of the time, it's possible to find a way to manage them. Here are some tips for soothing your stomach.