The Possible Link Between Birth Control & Autoimmune Disease

by Robin Elise Weiss, Ph.D. Health Professional

There are more than 100 diseases that fit into the category of autoimmune disease, and about 75 percent of the 50 million people living with autoimmune disease are women. Additionally, about 40 million women a year in the United States use birth control methods. But how does your birth control impact your autoimmune disease risk? Some birth control may put you at greater risk of certain conditions, while others may be protective. Read on to learn more.

hormonal birth control pills on white background

Hormonal Birth Control Can Affect Your Immune System

Many women who use birth control choose hormonal methods, like the pill, hormonal intrauterine device (IUD), implant, patch, and vaginal ring. Depending on the specific method, hormonal birth control usually is made up of forms of estrogen and/or progesterone. These powerful hormones can potentially wreak havoc on a body’s immune system.

Scientists in laboratory working on research

Hormones' Effects on the Body

Different hormones affect the body in different ways. Estrogen, for example, can cause cells to grow and make it easier to produce antibodies, while progesterone can affect T-cells. T-cells help the body respond to different invaders, like bacteria and viruses. Additionally, hormonal birth control can suppress the gonadotropins, hormones secreted in the pituitary gland. All of this can mean chaos for your immune system.

Read on to learn how some of the most common autoimmune diseases and birth control may interact.

Woman with stomach pain.

Crohn’s Disease and Birth Control

Research has found an association between risk of Crohn’s disease and a history of using birth control pills. Studies showed current birth control pill use increased the risk the most, and the risk was higher if you had used them for more than six years.

Doctor examining a patient for stomach pain.

Ulcerative Colitis and Birth Control

Ulcerative colitis (UC) is more common in people who use birth control pills. You are also at a greater risk of ulcerative colitis if you use birth control pills and smoke. While the length of time people used birth control pills did not alter their risk of UC, the higher the dose of estrogen, the more likely the patients were to have issues.

Woman discussing birth control with her doctor.

Lupus and Birth Control

The risks associated with combined hormonal birth control pill use and systemic lupus erythematosus are well-documented. What different studies disagree on is when you are most at risk from birth control use. For example, one study found that women were at the highest risk of developing lupus when they first started taking the pills, while another found the risk was raised throughout the use of birth control pills. Another showed any history of birth control pills to be a risk factor.

Doctor examining a patient's thyroid.

Thyroid Disease and Birth Control

The links between hyperthyroid and hypothyroid disease and birth control use vary. Interestingly enough, combined hormonal birth control pills seem to protect you against the risk of developing hyperthyroid disease. However, combined hormonal birth control pill use does not appear to alter hypothyroid risk.

happy young woman in wheelchair

Multiple Sclerosis and Birth Control

When it comes to multiple sclerosis (MS), it can be tricky to understand the risks associated with birth control use. For example, one study showed a significant increase in risk of developing MS in people who used birth control, but this increase could also be attributed to lifestyle (e.g., smoking status, what you eat, and environmental hazards, etc.). Another study also showed that using birth control pills is one factor that may increase the risk of MS.

woman scratching back with red skin

Autoimmune Skin Disorders and Birth Control

Some research has found an association between the risk of developing eczema and current use of combined hormonal birth control pills. There may also be an increased risk of developing the skin disorders pemphigus and vulval lichen sclerosis. The good news is that there appears to be no increased risk of scleroderma or psoriasis when you use combined hormonal birth control pills or have previously used them. If you currently use progesterone-only birth control methods, one study found, your risk of eczema and contact dermatitis, pruritis and related conditions, alopecia, acne, and urticaria” may be higher, too.

Patient talking to her doctor about autoimmune diseases and birth control.

Questions to Ask Your Doctor

Whether you already have an autoimmune disease diagnosis or not, it’s important to have a conversation with your doctor about birth control’s potential impact on your risk. For example, you might ask: Does this medication increase my risk of developing autoimmune disease? If yes, how much should I take that risk into account when making birth control decisions? Is there anything I can do to mitigate that risk? Is there an alternate form of birth control that might be better for my situation?

Woman discussing birth control with her doctor.

Birth Control Has Benefits, too

While the hormonal influences of birth control could potentially impact your autoimmune disease risk, it’s important to keep in mind that birth control can have many benefits, too — and that goes beyond pregnancy prevention. Many women decide these benfeits outweight any risks. Additionally, changing your birth control method does not guarantee that you won’t develop an autoimmune disease. Having a thorough discussion with your doctor about your personal health history, risk factors, and birth control needs can help you find the safest way forward for your situation.

Robin Elise Weiss, Ph.D.
Meet Our Writer
Robin Elise Weiss, Ph.D.

Robin Elise Weiss, Ph.D., LCCE, CLC, AdvCD(DONA) is a childbirth educator, doula, founder of, and the award-winning pregnancy and parenting author of “The Complete Illustrated Guide to Pregnancy” and more than 10 other books. Between her nine children, teaching childbirth classes, and attending births for more than two decades, she has built up an impressive and practical knowledge base. You can follow Robin on Twitter @RobinPregnancy, Instagram @Robineliseweiss, and Facebook @childbirthtrainings.