Supplements are regulated differently from food and drugs, which are reviewed by a very strict guidelines process managed by the Food and Drug Aministration. The supplement sector, instead, is regulated according to the Dietary and Supplement Health Act of 1994, (DSHEA). These guidelines are less strict, though they do have certain mandates for supplements and dietary supplement ingredients. Updates to the guidelines in 2010 and 2013 failed. The guidelines allow for a significant number of issues. Melatonin has problems.