Minor, short-term side effects are possible with all vaccinations. “The shingles vaccine may cause muscle pain, redness at the injection site, or headache,” Dr. Gopalan says.
Because the Shingrix vaccine does cause a strong response in your immune system, it may cause some more short-term side effects that are more intense than with other vaccines, Dr. Kaiser adds. Some people may experience fatigue, headache, shivering, fever, stomach pain, or nausea—with about one out of six people reporting that these side effects prevented them from doing some of their regular activities for a short while following vaccination. However, most symptoms were gone within a few days.