Hypercalcemia can be diagnosed by determining the level of calcium in the blood. Symptoms can include abdominal pain, lethargy, confusion, constipation, insomnia, dry and itchy skin, thirst, frequent urination, bloody or foamy urine, puffy eyes, swollen ankles, and muscle cramps. The best intervention is removal of the myeloma tumor. In addition, oral or intravenous bisphosphonates can be given. Resolving hypercalcemia is important because it can cause kidney damage and even death.