A current study is looking at what medications work best for lowering blood glucose levels. The Glycemic Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE), is a long-term study. Participants must have type 2 diabetes and have been diagnosed within the last ten years. They will randomly be given different medications, such as glimepiride, sitagliptin, liraglutide, and basal insulin glargine, plus metformin and will be followed for seven years. Researchers will be looking at side effects, glycemic control and overall health to determine which medications are most effective.